HILIC method development offers a unique opportunity for the successful separation of many polar analytes. However, it also presents a unique set of challenges to the liquid chromatographer. Advanced Chromatography Technologies Limited have published a new 38 page HILIC Method Development Technical Guide and A2 Wall Chart. The technical guide and wall chart illustrate a tried and tested approach to HILIC method development that can save hours of frustration and wasted effort. The guide covers the advantages and disadvantages of HILIC, mobile phase considerations, sample diluent effects as well as temperature, detectors, equilibration and column storage. Worked examples and chromatographic illustrations make this guide an invaluable tool for the liquid chromatographer.